02-29-2024, 04:38 PM
I haven't seen a thread on nootropics, and there are some here who may have good insight. I have limited experience using most nootropics, and I am fascinated by altered states, but I am extremely cautious in taking them.
I will use a loose definition of nootropic for this discussion. Something like: "a substance ingested for assisting a cognitive activity". I want to avoid using the word "enhanced" in my definition, because there are substances that meaningfully and temporarily reduce cognitive horsepower, but they alter your perception in a useful way regardless. One can even broaden the scope of “nootropic” to include non-chemical means. Exercise, sunbathing, intense sleep deprivation etc. can induce altered states which may be beneficial, but I want to limit the scope of my post to substances. Further, I'm not going to include things that are closer to a supplement, as their effects vary greatly on the person. I would put creatine and vitamin D in this supplement-nootropic category.
Alcohol: The lindiest of lindy drugs. The social effects of booze are widely known, so I won't go into that. I included it here because alcohol has been good at breaking writer's block for me. If I'm working a creative project, and I want to maximize my output after a drought of ideas, having a drink or two and then strapping myself to a keyboard is great.
Caffeine: I have been drinking coffee for most of my life daily, and I enjoy the ritual of making coffee in the morning. I prefer to have a single cup of very strong coffee, and depending on what I'm doing in the afternoon, I'll have another tea. I'll only drink it at night if I have a social activity, or if I have work that I need to finish. At high doses it increases my heart rate too much, and my focus can become too scattered to be useful. Energy drinks can be nice on occasion, I prefer red bull over anything else, mostly because of its flavor.
L-theanine: I find the combination of L-theanine and caffeine to be very pleasant. It occurs naturally in tea, with a higher ratio of L-theanine:caffeine in green tea. I think this is why green tea has a reputation for making people calm. Unfortunately, the half-life of L-theanine is 60 minutes, while the half life of caffeine is 5 hours, so it's effects wear off much more quickly. Overall, its effect is subtle, but definitely not just a placebo.
Nicotine: Another lindy entry in the list of nootropics. Nicotine has been around for a long time, although not nearly as long as caffeine. This is by far the most "fun" nootropic and therefore is the most dangerous. The method of ingestion, either consciously or not, seems to vary the effect. As a social activity, I find smoking to be enjoyable. It's a great way to pull someone out at a party and have a real conversation with them. On the other hand, habitual smoking reduces my athletic performance significantly, and so I avoid it entirely outside of social settings. Nicotine pouches seem to be the most effective for nootropic purposes. The release is slower than smoking, and so the cognitive effect lasts much longer. I find that nicotine at a low dose improves my ability to focus, especially beneficial for writing, because it reduces my inhibition to put thoughts down. Vaping seems like the most dangerous to me. The nicotine concentration is as high as a cigarette, but it's too easy to hit a vape unconsciously and thereby ruin any kind of benefit when you need it because of an increased tolerance. There's also very little social benefit to vaping, as you can't really share a vape with a stranger.
Nicotinamide (niacin): I rarely see this one discussed in the context of nootropics, but I think it's worthwhile to include. There are studies that show positive health effects, but I mostly care about the cognitive effect. After you take a regular dose, your skin becomes hot, very flushed, and possibly itchy. This feeling can be unpleasant, but afterwards I experience a kind of glowing effect, much like the end of a long run outside. It's been very good for me to use on occasion when I feel the need to reset myself, if I have been in a low speed mood, afterwards I feel "fresh".
Modafinil: This one is more potent than anything I've mentioned previously, but by far the most useful nootropic I've used. I would describe it as a cleaner caffeine. Shortly after ingestion, my focus becomes very one-track. I use it probably three or four times a month, at a low dosage, and I can work on a difficult task for several hours at a time. Unfortunately, the half life is extremely long, and so if I am going to use it, I only take it shortly after waking up, and only on days when I have nothing to attend to at night.
Wotan forgive me, but the nootropic subreddit has high quality first hand accounts. For these kinds of things, I think reddit can be very useful. Another great source is gwern's blog. He includes all of his first hand experiences but also scientific studies.
There's definitely a cultural read on nootropics. Someone here probably has a better take than I. It seems that the huberman/rogan/bryan johnson software guy is susceptible to becoming an optimizooor about these things. Their mistake is confusing a well ordered internal life for a higher cause. For me, I try to only use these for a concrete purpose, whether social or intellectual, and never as an end in itself.
I will use a loose definition of nootropic for this discussion. Something like: "a substance ingested for assisting a cognitive activity". I want to avoid using the word "enhanced" in my definition, because there are substances that meaningfully and temporarily reduce cognitive horsepower, but they alter your perception in a useful way regardless. One can even broaden the scope of “nootropic” to include non-chemical means. Exercise, sunbathing, intense sleep deprivation etc. can induce altered states which may be beneficial, but I want to limit the scope of my post to substances. Further, I'm not going to include things that are closer to a supplement, as their effects vary greatly on the person. I would put creatine and vitamin D in this supplement-nootropic category.
Alcohol: The lindiest of lindy drugs. The social effects of booze are widely known, so I won't go into that. I included it here because alcohol has been good at breaking writer's block for me. If I'm working a creative project, and I want to maximize my output after a drought of ideas, having a drink or two and then strapping myself to a keyboard is great.
Caffeine: I have been drinking coffee for most of my life daily, and I enjoy the ritual of making coffee in the morning. I prefer to have a single cup of very strong coffee, and depending on what I'm doing in the afternoon, I'll have another tea. I'll only drink it at night if I have a social activity, or if I have work that I need to finish. At high doses it increases my heart rate too much, and my focus can become too scattered to be useful. Energy drinks can be nice on occasion, I prefer red bull over anything else, mostly because of its flavor.
L-theanine: I find the combination of L-theanine and caffeine to be very pleasant. It occurs naturally in tea, with a higher ratio of L-theanine:caffeine in green tea. I think this is why green tea has a reputation for making people calm. Unfortunately, the half-life of L-theanine is 60 minutes, while the half life of caffeine is 5 hours, so it's effects wear off much more quickly. Overall, its effect is subtle, but definitely not just a placebo.
Nicotine: Another lindy entry in the list of nootropics. Nicotine has been around for a long time, although not nearly as long as caffeine. This is by far the most "fun" nootropic and therefore is the most dangerous. The method of ingestion, either consciously or not, seems to vary the effect. As a social activity, I find smoking to be enjoyable. It's a great way to pull someone out at a party and have a real conversation with them. On the other hand, habitual smoking reduces my athletic performance significantly, and so I avoid it entirely outside of social settings. Nicotine pouches seem to be the most effective for nootropic purposes. The release is slower than smoking, and so the cognitive effect lasts much longer. I find that nicotine at a low dose improves my ability to focus, especially beneficial for writing, because it reduces my inhibition to put thoughts down. Vaping seems like the most dangerous to me. The nicotine concentration is as high as a cigarette, but it's too easy to hit a vape unconsciously and thereby ruin any kind of benefit when you need it because of an increased tolerance. There's also very little social benefit to vaping, as you can't really share a vape with a stranger.
Nicotinamide (niacin): I rarely see this one discussed in the context of nootropics, but I think it's worthwhile to include. There are studies that show positive health effects, but I mostly care about the cognitive effect. After you take a regular dose, your skin becomes hot, very flushed, and possibly itchy. This feeling can be unpleasant, but afterwards I experience a kind of glowing effect, much like the end of a long run outside. It's been very good for me to use on occasion when I feel the need to reset myself, if I have been in a low speed mood, afterwards I feel "fresh".
Modafinil: This one is more potent than anything I've mentioned previously, but by far the most useful nootropic I've used. I would describe it as a cleaner caffeine. Shortly after ingestion, my focus becomes very one-track. I use it probably three or four times a month, at a low dosage, and I can work on a difficult task for several hours at a time. Unfortunately, the half life is extremely long, and so if I am going to use it, I only take it shortly after waking up, and only on days when I have nothing to attend to at night.
Wotan forgive me, but the nootropic subreddit has high quality first hand accounts. For these kinds of things, I think reddit can be very useful. Another great source is gwern's blog. He includes all of his first hand experiences but also scientific studies.
There's definitely a cultural read on nootropics. Someone here probably has a better take than I. It seems that the huberman/rogan/bryan johnson software guy is susceptible to becoming an optimizooor about these things. Their mistake is confusing a well ordered internal life for a higher cause. For me, I try to only use these for a concrete purpose, whether social or intellectual, and never as an end in itself.